Critical role of BIRC5 amplification in gastric cancer

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http://dx.doi.org/10.18081/jcc/016-06/1-15
Journal of Cellular Cancer  Volume 8, Issue 1, pages 16-22
Received December 02, 2015; accepted May 20, 2016; published June 13, 2016

Lianghai Zuo1, Jing Wang 2, Feng Xiong1, Jun Hou1*

Author Affiliations
*Corresponding Author: Electronic address: jun.hou@umac.mo. ¹Faculty of Health Science, University of Macau, Macau, China. ²Department of Internal Medicine, Xuzhou Central Hospital, Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, China

Abstract

Baculoviral IAP repeats containing 5 (BIRC5) is negatively encoded proteins regulation and inhibit apoptosis. BIRC5 has been demonstrated to be up-regulation in many types of cancer by unclear mechanism. Our objectives were to assess the incidence and ability of BIRC5 alterations to predict aggressive gastric cancer in a multicenter study. Gene BIRC5 amplification investigated by Multiple x Ligation-dependent Probe Amplification (MLPA) and is accompanied by detailed clinical information with long-term follow-up. In 409 gastric cancers, the overall rate of BIRC5 amplification was 62(15.1%). Significant associations were found between BIRC5 amplification with pathologic stage (P < 0.0021), metastasis (P = 0.002), and worse post-operative recurrence-free survival in young patients (P < 0.0021).  Our findings, suggest BIRC5 amplification assay could provide an important additional tool to making treatment decisions and gastric cancer monitor. Future studies will be needed to define BIRC5 singling pathway.

Keywords: BIRC5, Multiple x Ligation-dependent Probe Amplification, Gastric cancer

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