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Prognostic role of SAM68 in muscle invasive bladder cancer

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Research Article
Journal of Cellular Cancer Volume 2, Issue 1, pages 1-10
Received: February 12, 2010; accepted: May 02, 2010; published: June 03, 2010

Marcel B. Kelly¹, David B Mulier¹,², Steve Acquaviva¹, Marcel Todaro¹

Abstract

Bladder cancer, the fourth most common non-cutaneous malignancy in the United States, is characterized by high recurrence rate, with a subset of these cancers progressing to a deadly muscle invasive form of disease. SAM68 (Src-associated in mitosis of 68 kD), which plays a critical role in cancer, in this study, we aimed to quantify the SAM68 gene expression, and to determine the possibility that SAM68 can be used as prognostic role in muscle invasive bladder cancer. Western blot and immunohistochemistry (IHC) analysis revealed that the protein level of SAM68 was higher in (MIBC) tumor tissues. In addition, SAM68 stain revealed that SAM68 was positively correlated with clinical pathological variables such as tumor grade and tumor invasion. Taken together, these observations suggest that SAM68 could be an independent prognostic indicator for patients’ overall survival.

Keywords: SAM68; Bladder cancer; Muscle invasive; Tumor recurrence

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References

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108. [Abstract/Full-Text]
  2. Advanced Bladder Cancer Overview Collaboration. Neoadjuvant chemotherapy for invasive bladder cancer. Cochrane Database Syst Rev 2005:CD005246. [PubMed]
  3. Lukong KE, Richard S . Sam68, the KH domain-containing superSTAR. Biochim Biophys Acta 2003;1653:73-86. [PubMed]
  4. Advanced Bladder Cancer Meta-analysis Collaboration. Neoadjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis. Lancet 2003;361:1927–1934. [PubMed]
  5. Goebell PJ, Otto T, Rübben H. Perioperative chemotherapy in advanced bladder cancer: part I. Neoadjuvant treatment. Onkologie 2003;26:361–365. [PubMed]
  6. Song L,Wang L,Li Y, et al. Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells. J Pathol 2010; 222: 227-237. [PubMed]
  7. Montironi R, Lopez-Beltran A. The 2004 WHO classification of bladder tumors: a summary and commentary. Int J Surg Pathol 2005;13:143–153. [PubMed]
  8. Park J, Park S, Song C, Doo C, Cho YM, Ahn H, Kim CS. Effectiveness of adjuvant chemotherapy in transitional cell carcinoma of the urinary bladder with lymph node involvement and/or lymphovascular invasion treated by radical cystectomy. Urology 2007;70:257–262. [PubMed]
  9. Packeisen J, Korsching E, Herbst H, Boecker W, Buerger H. Demystified…tissue microarray technology. Mol Pathol 2003; 56:198-204. [Abstract/Full-text]
  10. Straume O, Akslen LA. Importance of vascular phenotype by basic fibroblast growth factor, and influence of the angiogenic factors basic fibroblast growth factor/fibroblast growth factor receptor-1and ephrin-A1/ EphA2 on melanoma progression. Am J Pathol 2002; 160:1009-19. [Abstract/Full-text]
  11. Collett K, Eide GE, Arnes J, et al. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res 2006; 12:1168–74. [PubMed]
  12. Zhang Z1, Li J, Zheng H. Expression and cytoplasmic localization of SAM68 is a significant and independent prognostic marker for renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 2009; 18(10):2685-93. [PubMed]
  13. Grossman HB, Natale RB, Tangen CM, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med 2003;349:859–866. [PubMed]
  14. Richard S,Vogel G,Huot ME,et al. Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis. Oncogene 2008; 27: 548-556. [PubMed]
  15. Solsona E, Iborra I, Ricos JV, Monros JL, Casanova J, Calabuig C. Feasibility of transurethral resection for muscle infiltrating carcinoma of the bladder: long-term followup of a prospective study. J Urol 1998;159:95–98. [PubMed]
  16. Herr HW. Transurethral resection of muscle-invasive bladder cancer: 10-year outcome. J Clin Oncol 2001;19:89–93. [PubMed]
  17. Hart S, Skinner EC, Meyerowitz BE, Boyd S, Lieskovsky G, Skinner DG. Quality of life after radical cystectomy for bladder cancer in patients with an ileal conduit, cutaneous or urethral kock pouch. J Urol 1999;162:77–81. [PubMed]
  18. Mori K, Nomata K, Noguchi M, Eguchi J, Hayashi N, Kanetake H. Long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy. Int J Urol 2007;14:591–594. [PubMed]
  19. Cookson MS. The surgical management of muscle invasive bladder cancer: a contemporary review. Semin Radiat Oncol 2005;15:10–18. [PubMed]
  20. Rödel C, Weiss C, Sauer R. Trimodality treatment and selective organ preservation for bladder cancer. J Clin Oncol 2006;24:5536–5544. [PubMed]
  21. Goebell PJ, Otto T, Rübben H. Perioperative chemotherapy in advanced bladder cancer: part I. Neoadjuvant treatment. Onkologie 2003; 26: 361–365. [PubMed]
  22. Montironi R, Lopez-Beltran A. The 2004 WHO classification of bladder tumors: a summary and commentary. Int J Surg Pathol 2005;13:143–153. [PubMed]
  23. Park J, Park S, Song C, Doo C, Cho YM, Ahn H, Kim CS. Effectiveness of adjuvant chemotherapy in transitional cell carcinoma of the urinary bladder with lymph node involvement and/or lymphovascular invasion treated by radical cystectomy. Urology 2007;70:257–262. [PubMed]
  24. Lee MY, Chou CY, Tang MJ, Shen MR. Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulation. Clin Cancer Res 2008; 14:4743-4750. [PubMed]
  25. Lukong KE, Larocque D, Tyner AL, Richard S. Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. J Biol Chem 2005; 280:38639-38647. [PubMed]
  26. Cote J, Boisvert FM, Boulanger MC, et al. Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell 2003; 4:274-287. [PubMed]
  27. Soros VB, Carvajal HV, Richard S, Cochrane AW. Inhibition of human immunodeficiency virus type 1 Rev function by a dominant-negative mutant of Sam68 through sequestration of unspliced RNA at perinuclear bundles. J Virol 2012; 75:8203–8215. [PubMed]
  28. Zhao FH1, Hu SY, Wang SM, et al. Association between high-risk human papillomavirus DNA load and different histological grades of cervical neoplasia. Zhonghua Yu Fang Yi Xue Za Zhi 2009; 43, 565–70. [PubMed]
  29. Taylor SJ, Resnick RJ, Shalloway D. SAM68 exerts separable effects on cell cycle progression and apoptosis. BMC Cell Biol 2004; 5:5–11. [PubMed]
  30. Liu K, Li L, Nisson PE, et al. Neoplastic trans-formation and tumorigenesis associated with SAM68 protein deficiency in cultured murine fibroblasts. J Biol Chem 2000; 275:40195–201. [PubMed]

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