Role of IL13Rα2 in induces esophageal cancer:crosstalk FAK/PI3K signaling pathway

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Journal of Cellular Cancer  Volume 6, Issue 1, pages 26-38
Published: June 21, 2014

Richard H. Morris, Prateek, Hoque, Mishra Wang, Jonathan A. Coombes, Gabriel Tyritzis, John Shimizu

Abstract

Esophageal cancer is the eighth most common incident cancer in the world and sixth in cancer mortality. The interleukin-13 receptor alpha2 (IL13Rα2) is a cell surface receptor that is over-expressed by a subset of many solid tumor, and plays a critical role in cancer invasion and metastasis, but the mechanistic features of this process are obscure in esophageal tumor. We investigated the possibility of up-regulating cell surface IL13Rα2 levels on esophageal cancer through crosstalk FAK/PI3K signaling pathway. IL13Rα2 mRNA levels quantified by qPCR, to identify the FAK/PI3K signaling pathway induced esophageal cancer cell we performed protein immunoprecipitation followed by tandem mass spectrometry. One of the principle observations resulting from these studies is that FAK and PI3K signaling network regulate the activity of IL13Rα2 in esophageal cancer, further needs to identify the  key mediator of IL13Rα2 in invasion and liver metastasis in esophageal cancer.

Keywords: IL13Rα2; Esophageal cancer; FAK/PI3K signaling pathway; qPCR

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Richard H. Morris, Prateek, Hoque, Mishra Wang, Jonathan A. Coombes, Gabriel Tyritzis, John Shimizu. Role of IL13Rα2 in induces esophageal cancer:crosstalk FAK/PI3K signaling pathway. Journal of cellular cancer 2014; 6(1):26-38.