Critical relationship between neutrophil/lymphocyte ratio with overall survival breast cancer

Research Article
Journal of Cellular Cancer  Volume 7, Issue 1, pages 17-29
Published: June 12, 2015

Philippe Kainuma, Yannick Yamamoto, Nobuhiro Takiguchi, Kimberly Rzymkiewicz, Jean-François Eduardo


The immune response to various physiological challenges is characterized by increased neutrophil and decreased lymphocyte counts, and NLR is often recognized as an inflammatory marker to assess the severity of the disease. Further, there is a close relationship between systemic inflammation and cancer development and progression, whereas its association with braest cancer remains unclear. Univariate and multivariate cox proportional hazards models were used to investigate the influence of the neutrophil-to-lymphocyte ratio (NLR) and cancer of the breast cancer. In conclusion, a high preoperative N/L ratio may be a convenient biomarker to identify patients with a poor prognosis breast cancer.

Keywords: Neutrophil-to-lymphocyte ratio; Inflammatory marker; Breast cancer; Cancer

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Philippe Kainuma, Yannick Yamamoto, Nobuhiro Takiguchi, Kimberly Rzymkiewicz, Jean-François Eduardo. Critical relationship between neutrophil/lymphocyte ratio with overall survival breast cancer. Journal of cellular cancer 2015; 7(1):17-29.