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Minoru B.Tada¹, Suzan Kamath, Lindsell E. Norton, Kathleen B. Loomes∗
Abstract
Ovarian cancer is the most lethal gynecologic malignancy. In recent data have shown constitutive upregulation of the Notch1 signaling pathway in many forms of solid and hematological malignancies. However, it remains unclear whether this signaling pathway is activated in ovarian cancer cells. In the present study, the aim was to study the role of Notch1 signaling and Wnt in ovarian cancer cells by investigating the cellular localization of Notch1-associated proteins in tissue samples from ovarian cancer patients. Human tissue samples were obtained from 218 ovarian cancer patients who had undergone surgery without adjuvant chemotherapy or radiation. The correlation value between translocation of Notch1, Wnt and survival rate in ovarian cancer patients after surgery was studied. By immunohistochemistry staining and with real-time quantitative PCR, the expression of Notch1, as well as Notch 2-4 and Wnt were examined in ovarian cancer and normal control tissue samples. The data were analyzed in reference to the patients' clinicopathological characteristics and the effects of these results on patient prognosis were determined. In conclusion, Notch1 and Wnt co-activation are involved in ovarian cancer cell progression and more investigation needs in future.
Keywords: Ovarian cancer cells; Notch1; Wnt
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